Here is a description of the Electro-Stimulation Biofeedback (BEST ™) Technology from Avazzia.

The therapeutic applications are based on the increase in cell capacity and the stimulation of unmyelinated C nerve fibers and myelinated A nerve fibers for the secretion of neuropeptides leading to a cascade of several other neuroactive substances such as neurotransmitters, histamine and 5-HT (serotonin). In addition, neuropeptide synthesis is overregulated which leads to a quantitative increase in the production of endogenous neuropeptides by C fibers.

The pulses of the BEST devices induce the secretion of neuropeptides mainly by the C nerve fibers, and have deep and broad effects, which trigger complex chains of regulation and cascades. Several biochemical pathways that use many types of neurotransmitters, hormones and cytokines are involved. Although the half-life of peptides in body fluids is relatively short, other mediators in the cascades survive for several hours. Certain regulatory peptides act on genomic activity to alter gene expression and change biochemical synthesis. BEST electrical signals can reprogram tissues locked into chronic and dysfunctional vegetative states by inducing the synthesis of regulatory peptides.

BEST impulses are also transmitted by the nervous pathways afferent to the Central Nervous System and generate various 

1) Segmental spinal reflexes using efferent signals sent by the spinal cord to organs associated with that segment or signals returning to the local tissue receiving the impulse;

2) Systemic reactions such as endorphin induction by efferent signals from cortical and subcortical regions of the brain, leading directly to reduction of pain for example.

An afferent nerve conducts impulses from peripheral nerve endings to the brain (Central Nervous System).

An efferent nerve leads impulses from the brain (CNS) to peripheral receptors.

Let's continue with a little chemical concepts!

BEST pulses have a direct effect on blood perfusion. The clinically observable increases in tissue perfusion of the treated areas are due to vasodilation induced by neuropeptides, and in particular, substance P. 

A combination of axon reflexes induced by signals from the BEST device also emits other vasoactive substances such as kinins, prostaglandins, cytokines and nitric oxide. The end result is that blood flow to a treated area is dramatically increased.

Other neuropeptides and endocrine secretions from BEST pulses control inflammation. Complementary attachment and tissue injury due to immune aggression is suppressed, and cellular immunity is enhanced by macrophage proliferation, activation, chemotaxis, and removal of extracellular debris.

In short, the cells are cleaned, repaired and can then resume their normal role!

BEST technology from Avazzia, a breakthrough in the field of non-invasive care.

Practitioners and studies show that patients can recover faster (up to 70%) by interacting directly with one of the human body's primary control mechanisms: neural responses.

Experiences show that the right stimulation makes the human body able to allocate more internal healing resources to decrease and even eliminate pain and improve chronic diseases as well as serious injuries.

The internal healing pharmacy consists of neurotransmitters including Neuropeptides!